Document Detail

The START trial-measurements in semi-anatomical breast and chest wall phantoms.
MedLine Citation:
PMID:  11474935     Owner:  NLM     Status:  MEDLINE    
This paper describes dosimetry measurements performed prior to departments entering patients into the START Trial, a breast fractionation trial. Absolute and relative doses were measured in semi-anatomical breast and chest wall phantoms, as part of a quality assurance programme visit. Doses were measured using an ionization chamber and the resulting distributions were compared with those calculated by the department. The mean ratio of measured to calculated dose at the START reference point was found to be 0.981 for the breast phantom and 0.978 for the chest wall phantom. This average measured dose was significantly less than the prescribed dose (p < 0.001). Differences were found between 2D and 3D planning systems and for departments using cobalt 60 beams. A number of departments had deviations of greater than 4%, which was the tolerance applied for this trial. It is essential for dose measurements of this type to be performed for randomized clinical trials involving radiotherapy, particularly where dose fractionation regimes are being compared.
K Venables; E Winfield; A Deighton; E Aird; P Hoskin;
Related Documents :
15730985 - Radiation doses received in the uk breast screening programme in 2001 and 2002.
18975685 - Peripheral dose measurements for 6 and 18 mv photon beams on a linear accelerator with ...
8609025 - An approach to evaluating bias and uncertainty in estimates of external dose obtained f...
19394875 - Pediatric mdct: towards assessing the diagnostic influence of dose reduction on the det...
11669455 - Pharmacokinetics of the beta-carboline norharman in man.
3155605 - Antiandrogenic effects of topically applied spironolactone on the hamster flank organ.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physics in medicine and biology     Volume:  46     ISSN:  0031-9155     ISO Abbreviation:  Phys Med Biol     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-27     Completed Date:  2001-12-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1937-48     Citation Subset:  IM    
Marie Curie Research Wing, Mount Vernon Hospital, Northwood, Middlesex, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Breast / pathology*
Clinical Trials as Topic
Cobalt Radioisotopes* / therapeutic use
Dose Fractionation
Particle Accelerators / instrumentation*
Phantoms, Imaging
Thorax / pathology*
Reg. No./Substance:
0/Cobalt Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Regional hyperthermia applicator design using FDTD modelling.
Next Document:  Effects of crosslinker fraction in polymer gel dosimeters using FT Raman spectroscopy.