Document Detail


The START trial-measurements in semi-anatomical breast and chest wall phantoms.
MedLine Citation:
PMID:  11474935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper describes dosimetry measurements performed prior to departments entering patients into the START Trial, a breast fractionation trial. Absolute and relative doses were measured in semi-anatomical breast and chest wall phantoms, as part of a quality assurance programme visit. Doses were measured using an ionization chamber and the resulting distributions were compared with those calculated by the department. The mean ratio of measured to calculated dose at the START reference point was found to be 0.981 for the breast phantom and 0.978 for the chest wall phantom. This average measured dose was significantly less than the prescribed dose (p < 0.001). Differences were found between 2D and 3D planning systems and for departments using cobalt 60 beams. A number of departments had deviations of greater than 4%, which was the tolerance applied for this trial. It is essential for dose measurements of this type to be performed for randomized clinical trials involving radiotherapy, particularly where dose fractionation regimes are being compared.
Authors:
K Venables; E Winfield; A Deighton; E Aird; P Hoskin;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physics in medicine and biology     Volume:  46     ISSN:  0031-9155     ISO Abbreviation:  Phys Med Biol     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-27     Completed Date:  2001-12-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1937-48     Citation Subset:  IM    
Affiliation:
Marie Curie Research Wing, Mount Vernon Hospital, Northwood, Middlesex, UK. karen_venables@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Breast / pathology*
Clinical Trials as Topic
Cobalt Radioisotopes* / therapeutic use
Dose Fractionation
Female
Humans
Particle Accelerators / instrumentation*
Phantoms, Imaging
Thorax / pathology*
Chemical
Reg. No./Substance:
0/Cobalt Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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