| The STAR of the DLC family. | |
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MedLine Citation:
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PMID: 23316797 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract RhoGTPases are defined as a family of 20 small G proteins playing important roles in almost every cellular process. RhoGTPases are guanine nucleotide-binding proteins existing in two forms: the active form which is GTP bound and the inactive one that being GDP bound. RhoGTPase-activating proteins known as RhoGAPs constitute one of the major classes of regulators of RhoGTPases. They act as negative regulators of the RhoGTPases by enhancing their slow intrinsic GTPase activity. STARD13, a GTPase activating protein (GAP) for RhoGTPases, has been described as a tumor suppressor in hepatocellular carcinoma. In the present review, we discuss the family of RhoGTPases, their regulation and their RhoGAPs, focusing mainly on STARD13. |
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Authors:
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Sally El-Sitt; Mirvat El-Sibai |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-15 |
Journal Detail:
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Title: Journal of receptor and signal transduction research Volume: - ISSN: 1532-4281 ISO Abbreviation: J. Recept. Signal Transduct. Res. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9509432 Medline TA: J Recept Signal Transduct Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Natural Sciences, Lebanese American University , Beirut Campus, Beirut , Lebanon. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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