| ST2: a novel remodeling biomarker in acute and chronic heart failure. | |
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MedLine Citation:
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PMID: 20425491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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ST2, a member of the interleukin-1 receptor family, is a novel biomarker of mechanical stress measurable in serum that has been shown in animal and in vitro models to be physiologically linked to cardiac hypertrophy, fibrosis, and ventricular dysfunction. In patients with acute myocardial infarction and heart failure (HF), an elevated serum level of the soluble isoform of ST2 is associated with an increased risk of mortality or future HF, independent of natriuretic peptides, and correlates with markers of ventricular structure and function. In acute HF, elevated soluble ST2 levels strongly associate with the presence and severity of the disease and forecast short- and long-term mortality independent of other traditional clinical, biochemical, and echocardiographic markers of risk. This review discusses the biology and physiology of ST2, as well as its implications on the pathogenesis and prognosis of patients with acute coronary syndromes or acute and chronic HF syndromes. |
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Authors:
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Ravi V Shah; James L Januzzi |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current heart failure reports Volume: 7 ISSN: 1546-9549 ISO Abbreviation: Curr Heart Fail Rep Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101196487 Medline TA: Curr Heart Fail Rep Country: United States |
Other Details:
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Languages: eng Pagination: 9-14 Citation Subset: IM |
Affiliation:
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Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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blood* Animals Biological Markers / blood Heart Failure / blood* Humans Receptors, Cell Surface / blood*, physiology Receptors, Interleukin / blood*, physiology Risk Factors Severity of Illness Index Ventricular Remodeling* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/IL1RL1 protein, human; 0/Il1rl1 protein, mouse; 0/Receptors, Cell Surface; 0/Receptors, Interleukin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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