Document Detail


ST2: a novel remodeling biomarker in acute and chronic heart failure.
MedLine Citation:
PMID:  20425491     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ST2, a member of the interleukin-1 receptor family, is a novel biomarker of mechanical stress measurable in serum that has been shown in animal and in vitro models to be physiologically linked to cardiac hypertrophy, fibrosis, and ventricular dysfunction. In patients with acute myocardial infarction and heart failure (HF), an elevated serum level of the soluble isoform of ST2 is associated with an increased risk of mortality or future HF, independent of natriuretic peptides, and correlates with markers of ventricular structure and function. In acute HF, elevated soluble ST2 levels strongly associate with the presence and severity of the disease and forecast short- and long-term mortality independent of other traditional clinical, biochemical, and echocardiographic markers of risk. This review discusses the biology and physiology of ST2, as well as its implications on the pathogenesis and prognosis of patients with acute coronary syndromes or acute and chronic HF syndromes.
Authors:
Ravi V Shah; James L Januzzi
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current heart failure reports     Volume:  7     ISSN:  1546-9549     ISO Abbreviation:  Curr Heart Fail Rep     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101196487     Medline TA:  Curr Heart Fail Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9-14     Citation Subset:  IM    
Affiliation:
Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / blood*
Animals
Biological Markers / blood
Heart Failure / blood*
Humans
Receptors, Cell Surface / blood*,  physiology
Receptors, Interleukin / blood*,  physiology
Risk Factors
Severity of Illness Index
Ventricular Remodeling*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/IL1RL1 protein, human; 0/Il1rl1 protein, mouse; 0/Receptors, Cell Surface; 0/Receptors, Interleukin

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