Document Detail

ST2: a novel biomarker for heart failure.
MedLine Citation:
PMID:  20465500     Owner:  NLM     Status:  MEDLINE    
ST2, an IL-1 receptor family member with transmembrane (ST2L) and soluble (sST2) isoforms, was originally described in the context of inflammatory and autoimmune diseases. However, after the identification of IL-33 as the functional ligand for ST2, and conceptualization of the role of ST2/IL-33 signaling in cardiac remodeling, sST2 has emerged as a novel cardiovascular biomarker for the presence of ventricular biomechanical overload. Concentrations of sST2 have been implicated in the presence and severity of heart failure with particular value for prognostication. We will review the use of sST2 as a prognostic marker in heart failure, including present and future directions in this exciting area.
Anju Bhardwaj; James L Januzzi
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of molecular diagnostics     Volume:  10     ISSN:  1744-8352     ISO Abbreviation:  Expert Rev. Mol. Diagn.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-14     Completed Date:  2010-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120777     Medline TA:  Expert Rev Mol Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  459-64     Citation Subset:  IM    
Cardiology Division, Massachusetts General Hospital, 32 Fruit Street, Yawkey 5984, Boston, MA 02114, USA.
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MeSH Terms
Biological Markers / metabolism*
Coronary Disease / physiopathology
Dyspnea / blood,  physiopathology
Heart Failure / diagnosis*,  metabolism,  physiopathology
Natriuretic Peptides / blood
Receptors, Cell Surface / genetics,  metabolism*
Risk Factors
Ventricular Remodeling
Reg. No./Substance:
0/Biological Markers; 0/IL1RL1 protein, human; 0/Natriuretic Peptides; 0/Receptors, Cell Surface

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