Document Detail


ST2 and adrenomedullin in heart failure.
MedLine Citation:
PMID:  19631176     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ST2 is the receptor for interleukin-33, a cytokine with antihypertrophic and antifibrotic effects on the myocardium. Serum levels of the soluble form of ST2 serve as a biomarker for ventricular biomechanical strain and provide prognostic information in patients who have symptomatic heart failure. Adrenomedullin is a vasoactive peptide whose actions run counter to the physiologic derangements of clinical heart failure. It appears that measurements of serum adrenomedullin levels can be used to identify those patients who have advanced heart failure and who are at increased risk for heart failure-related death.
Authors:
Rahul Kakkar; Richard T Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart failure clinics     Volume:  5     ISSN:  1551-7136     ISO Abbreviation:  -     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231934     Medline TA:  Heart Fail Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  515-27     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA. rkakkar@partners.org
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MeSH Terms
Descriptor/Qualifier:
Adrenomedullin / physiology*
Biological Markers / blood
Heart Failure / blood*,  diagnosis*
Humans
Receptors, Cell Surface / blood*,  physiology
Receptors, Interleukin-1 / blood*,  physiology
Chemical
Reg. No./Substance:
0/Biological Markers; 0/IL1RL1 protein, human; 0/Receptors, Cell Surface; 0/Receptors, Interleukin-1; 148498-78-6/Adrenomedullin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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