| ST-segment elevation myocardial infarction due to early and late stent thrombosis a new group of high-risk patients. | |
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MedLine Citation:
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PMID: 18565395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of this retrospective study was to compare clinical and angiographic outcomes between patients presenting with ST-segment elevation myocardial infarction (STEMI) due to stent thrombosis (ST) and de novo coronary thrombosis. BACKGROUND: There are limited data for procedural and mid-term outcomes of patients with ST presenting with STEMI. METHODS: From January 2004 to March 2007, 115 definite ST patients were observed: 92 (80%) of them presented as STEMI and were compared with a consecutive group of 98 patients with de novo STEMI. All patients underwent primary percutaneous coronary intervention. Primary end points were successful angiographic reperfusion and distal embolization. Major adverse cardiovascular and cerebrovascular events (MACCE), evaluated at 6-month follow-up, were defined as death, nonfatal myocardial reinfarction, target vessel revascularization, and cerebrovascular accident. RESULTS: Successful reperfusion rate was lower in patients with ST (p < 0.0001), whereas distal embolization rate was higher (p = 0.01) in comparison with patients with de novo STEMI. Stent thrombosis proved to be an independent predictor of unsuccessful reperfusion at propensity-adjusted binary logistic regression (odds ratio 6.8, p = 0.004). In-hospital MACCE rate was higher in patients with ST (p = 0.003), whereas no differences were observed at 6-month follow-up among hospital survivors between the 2 groups (p = 0.7). CONCLUSIONS: Stent thrombosis identifies a subgroup of patients with STEMI with poor angiographic and early clinical outcomes, suggesting that the management of these patients should be improved. |
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Authors:
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Tania Chechi; Sabine Vecchio; Guido Vittori; Gabriele Giuliani; Alessio Lilli; Gaia Spaziani; Lorenzo Consoli; Giorgio Baldereschi; Giuseppe G L Biondi-Zoccai; Imad Sheiban; Massimo Margheri |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 51 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-20 Completed Date: 2008-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 2396-402 Citation Subset: AIM; IM |
Affiliation:
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Cardiologia e Cardiologia Invasiva 2, A.O.U. Careggi, Florence, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Angiography Coronary Thrombosis / complications*, mortality, physiopathology Drug-Eluting Stents / adverse effects* Female Follow-Up Studies Heart Conduction System / physiopathology* Humans Italy Male Middle Aged Myocardial Infarction / etiology*, mortality, physiopathology Myocardial Reperfusion Retrospective Studies Risk Factors Time Factors Treatment Outcome |
| Comments/Corrections | |
Comment In:
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J Am Coll Cardiol. 2008 Jun 24;51(25):2403-6
[PMID:
18565396
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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