| ST-elevation myocardial infarction patients can be enrolled in randomized trials before emergent coronary intervention without sacrificing door-to-balloon time. | |
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MedLine Citation:
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PMID: 19699863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Multicenter trials are necessary to compare the effectiveness of new drugs and devices for patients with ST-elevation myocardial infarction (STEMI) percutaneous coronary intervention (PCI). However, enrollment of STEMI patients in clinical trials could be detrimental to patients if it significantly delayed reperfusion therapy. We sought to determine whether STEMI patients treated with PCI could be enrolled in clinical trials without prolonging door-to-balloon times. METHODS: At a single PCI center between October 17, 2004, and December 31, 2007, patients were enrolled in 1 of 4 trials requiring central enrollment and informed consent if (1) a study was actively enrolling, (2) the patient met inclusion/exclusion criteria, (3) and a study nurse was available. Median door-to-balloon times were compared for patients enrolled in clinical trials compared to those not enrolled. RESULTS: Of 581 STEMI patients treated with PCI, 123 were enrolled in clinical trials and 458 were not. For patients transferred for PCI, community hospital door-to-balloon times were similar for research and nonresearch patients (104 vs 108 minutes, P = .4). For patients presenting directly to the PCI center, median door-to-balloon times were similar for research (55 minutes) and nonresearch patients (44 minutes, P = .5) after adjustment for age, culprit artery, and operator. CONCLUSIONS: Patients with STEMI may be enrolled in clinical trials with no significant delay in achieving reperfusion. For patients presenting directly to the PCI center, median door-to-balloon times well under 90 minutes can be achieved even with enrollment into clinical trials. |
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Authors:
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James C Blankenship; Kimberly A Skelding; Thomas D Scott; Jeremy Buckley; Deborah K Zimmerman; Amy Temple; Jennifer Sartorius; Enrique Jimenez; Peter B Berger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 158 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-24 Completed Date: 2009-10-08 Revised Date: 2010-02-23 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 400-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Geisinger Medical Center, Danville, PA 17822, USA. jblankenship@geisinger.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary* Electrocardiography Female Humans Male Middle Aged Myocardial Infarction / diagnosis, therapy* Randomized Controlled Trials as Topic* Time Factors |
| Comments/Corrections | |
Comment In:
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Am Heart J. 2010 Feb;159(2):e1
[PMID:
20152207
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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