Document Detail

ST-changes in ECG at rest or during exercise indicate a high risk of severe coronary lesions after an episode of unstable coronary artery disease.
MedLine Citation:
PMID:  8112905     Owner:  NLM     Status:  MEDLINE    
After an episode of unstable coronary artery disease, 190 patients performed a predischarge exercise test. A postdischarge exercise test and coronary angiography was performed by 172 patients after 1 month. A subgroup of 104 men performed both exercise tests with a computer-aided system. More sophisticated methods of evaluating the ECG reaction during exercise were not diagnostically superior to the simple identification of ST-depression of > or = 0.1 mV. ST-depression in ECG at rest indicated a 70% risk of severe coronary lesions and in such patients, the ECG reaction at exercise carried no additional diagnostic information. Stepwise multiple regression analysis showed that ST-depression and low maximal work load were the most important exercise variables for identification of severe coronary lesions. Using a combination of these parameters, the sensitivity and specificity for identification of severe coronary lesions were, respectively, 77% and 61% predischarge and 77% and 70% after 1 month.
J E Karlsson; A Björkholm; E Nylander; J Ohlsson; E Swahn; L Wallentin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  42     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-03-25     Completed Date:  1994-03-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  47-55     Citation Subset:  IM    
Department of Internal Medicine, County Hospital Ryhov, Jönköping, Sweden.
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MeSH Terms
Coronary Angiography
Coronary Disease / diagnosis*,  drug therapy,  epidemiology
Double-Blind Method
Electrocardiography / methods*
Exercise Test
Middle Aged
Regression Analysis
Risk Factors
Sensitivity and Specificity
Signal Processing, Computer-Assisted
Tissue Plasminogen Activator / therapeutic use
Reg. No./Substance:
EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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