Document Detail


SSeCKS is a suppressor in Schwann cell differentiation and myelination.
MedLine Citation:
PMID:  19757038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Src-suppressed protein kinase C substrate (SSeCKS) plays an important role in the differentiation process. In regeneration of sciatic nerve injury, expression of SSeCKS decreases, mainly in Schwann cells. However, the function of SSeCKS in Schwann cells differentiation remains unclear. We observed that SSeCKS was decreased in differentiated Schwann cells. In long-term SSeCKS-reduced Schwann cells, cell morphology changed and myelin gene expression induced by cAMP was accelerated. Myelination was also enhanced in SSeCKS-suppressed Schwann cells co-culture with dorsal root ganglion (DRG). In addition, we found suppression of SSeCKS expression promoted Akt serine 473 phosphorylation in cAMP-treated Schwann cells. In summary, our data indicated that SSeCKS was a negative regulator of myelinating glia differentiation.
Authors:
Yuhong Ji; Tao Tao; Chun Cheng; Huiguang Yang; Youhua Wang; Junling Yang; Haiou Liu; Xinxing He; Huiming Wang; Aiguo Shen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-16
Journal Detail:
Title:  Neurochemical research     Volume:  35     ISSN:  1573-6903     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-26     Citation Subset:  IM    
Affiliation:
Laboratory Center, Affiliated Hospital of Nantong University, and The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, 226001 Nantong, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
A Kinase Anchor Proteins / physiology*
Animals
Cell Cycle Proteins / physiology*
Cell Differentiation / drug effects*
Coculture Techniques
Cyclic AMP / physiology
Down-Regulation
Ganglia, Spinal / physiology
Myelin Sheath / physiology*
Proto-Oncogene Proteins c-akt / metabolism
Rats
Schwann Cells / cytology*,  physiology
Grant Support
ID/Acronym/Agency:
//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/A Kinase Anchor Proteins; 0/Akap12 protein, rat; 0/Cell Cycle Proteins; 60-92-4/Cyclic AMP; EC 2.7.11.1/Proto-Oncogene Proteins c-akt

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