Document Detail

SSRIs, adolescents, and aggression: tempering human implications regarding SSRI-induced aggression in hamsters: comment on Ricci and Melloni (2012).
MedLine Citation:
PMID:  23025836     Owner:  NLM     Status:  MEDLINE    
The safety and efficacy of selective serotonin reuptake inhibitors (SSRIs) in adolescents is a topic of great import, complexity, and controversy. Conflicting evidence derived from clinical trials, translational research, and basic science demands that investigators in the field use critical thinking in the synthesis of evidence from varying sources. The new study by Ricci and Melloni presented in the current issue of this journal shows that exposure to low-dose fluoxetine during adolescence predisposes Syrian hamsters to offensive aggression, with demonstrable neurophysiologic changes. This work adds to the understanding of the mammalian neuropathways of aggression, but is limited in its direct generalizability to human adolescent clinical populations.
David H Rubin; John T Walkup
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  126     ISSN:  1939-0084     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-03-14     Revised Date:  2013-03-25    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  742-7     Citation Subset:  IM    
Copyright Information:
PsycINFO Database Record (c) 2012 APA, all rights reserved.
Department of Psychiatry, Division of Child and Adolescent Psychiatry, Weill Cornell Medical College and New York-Presbyterian Hospital, New York, NY 10065, USA.
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MeSH Terms
Aggression / drug effects*
Fluoxetine / administration & dosage*
Neurons / drug effects*
Serotonin / metabolism*
Serotonin Uptake Inhibitors / administration & dosage*
Vasopressins / metabolism*
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 11000-17-2/Vasopressins; 50-67-9/Serotonin; 54910-89-3/Fluoxetine
Comment On:
Behav Neurosci. 2012 Oct;126(5):640-53   [PMID:  23025830 ]
Comment In:
Behav Neurosci. 2013 Feb;127(1):130-2   [PMID:  23398445 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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