Document Detail

SSRI use during pregnancy and risk of stillbirth and neonatal mortality.
MedLine Citation:
PMID:  23361562     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The authors investigated whether in utero exposure to selective serotonin reuptake inhibitors (SSRIs) increases the risk of stillbirth or neonatal mortality.
METHOD: The authors conducted a population-based cohort study using the Danish Fertility Database to identify every birth in Denmark between 1995 and 2008. Time of exposure to SSRIs was calculated on the basis of standard treatment dosages and dispensed pack sizes according to the prescription register. Exposure was divided into first-, second-, and third-trimester exposure. Multivariate logistic regression models were used.
RESULTS: The authors identified 920,620 births; the incidence of stillbirths was 0.45%, and the incidence of neonatal mortality was 0.34%. A total of 12,425 offspring were exposed to an SSRI during pregnancy. Stillbirth was not associated with first-trimester SSRI use (adjusted odds ratio=0.77, 95% CI=0.43-1.36), first- and second-trimester use (odds ratio=0.84, 95% CI=0.40-1.77), or first-, second-, and third-trimester use (odds ratio=1.06, 95% CI=0.71-1.58). Neonatal mortality was not associated with SSRI first-trimester use (odds ratio=0.56, 95% CI=0.25-1.24), first- and second-trimester use (odds ratio=0.90, 95% CI=0.37-2.17), or first-, second-, and third-trimester use (odds ratio=1.27, 95% CI=0.82-1.99).
CONCLUSIONS: This study found no association between exposure to SSRIs during pregnancy and stillbirth or neonatal mortality.
Espen Jimenez-Solem; Jon Trærup Andersen; Morten Petersen; Kasper Broedbaek; Anders Rune Lander; Shoaib Afzal; Christian Torp-Pedersen; Henrik E Poulsen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  170     ISSN:  1535-7228     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-01     Completed Date:  2013-04-15     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  AIM; IM    
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MeSH Terms
Antidepressive Agents / administration & dosage*,  therapeutic use
Cohort Studies
Cross-Sectional Studies
Depressive Disorder / drug therapy*
Drug Therapy, Combination
Gestational Age
Infant Mortality*
Infant, Newborn
Odds Ratio
Pregnancy Complications / drug therapy*
Risk Factors
Serotonin Uptake Inhibitors / adverse effects*,  therapeutic use
Stillbirth / epidemiology*
Young Adult
Reg. No./Substance:
0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors
Comment In:
Ann Intern Med. 2013 Jun 18;158(12):JC12   [PMID:  23778924 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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