Document Detail


SRD5A1 Genotype Frequency Differences in Women with Mild versus Severe Premenstrual Symptoms.
MedLine Citation:
PMID:  22273344     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The aims of this small pilot study were to explore the association between premenstrual symptom severity and two genes from the gamma-aminobutyric acid (GABA) pathway: steroid-5-alpha-reductase, alpha polypeptide 1 (SRD5A1) and gamma-aminobutyric acid receptor subunit alpha-4 (GABRA4). Saliva samples were obtained from a convenience sample of 19 Caucasian females ages 18-25 years, ten cases and nine controls. Deoxyribonucleic acid (DNA) was isolated, and genotyping performed on ten single nucleotide polymorphisms (SNPs). Ten percent of cases and 44% of controls had the cytosine/cytosine (C/C) genotype for the SRD5A1 SNP, rs501999 indicating that this genotype may protect women against severe premenstrual symptoms. Replication of this study using an adequately powered sample size is warranted.
Authors:
Marlene Adams; Susan McCrone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Issues in mental health nursing     Volume:  33     ISSN:  1096-4673     ISO Abbreviation:  Issues Ment Health Nurs     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907126     Medline TA:  Issues Ment Health Nurs     Country:  England    
Other Details:
Languages:  eng     Pagination:  101-8     Citation Subset:  N    
Affiliation:
University of Delaware, School of Nursing, Newark, Delaware, USA.
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