Document Detail

SRD5A1 Genotype Frequency Differences in Women with Mild versus Severe Premenstrual Symptoms.
MedLine Citation:
PMID:  22273344     Owner:  NLM     Status:  In-Data-Review    
The aims of this small pilot study were to explore the association between premenstrual symptom severity and two genes from the gamma-aminobutyric acid (GABA) pathway: steroid-5-alpha-reductase, alpha polypeptide 1 (SRD5A1) and gamma-aminobutyric acid receptor subunit alpha-4 (GABRA4). Saliva samples were obtained from a convenience sample of 19 Caucasian females ages 18-25 years, ten cases and nine controls. Deoxyribonucleic acid (DNA) was isolated, and genotyping performed on ten single nucleotide polymorphisms (SNPs). Ten percent of cases and 44% of controls had the cytosine/cytosine (C/C) genotype for the SRD5A1 SNP, rs501999 indicating that this genotype may protect women against severe premenstrual symptoms. Replication of this study using an adequately powered sample size is warranted.
Marlene Adams; Susan McCrone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Issues in mental health nursing     Volume:  33     ISSN:  1096-4673     ISO Abbreviation:  Issues Ment Health Nurs     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907126     Medline TA:  Issues Ment Health Nurs     Country:  England    
Other Details:
Languages:  eng     Pagination:  101-8     Citation Subset:  N    
University of Delaware, School of Nursing, Newark, Delaware, USA.
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