| SRD5A1 Genotype Frequency Differences in Women with Mild versus Severe Premenstrual Symptoms. | |
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MedLine Citation:
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PMID: 22273344 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The aims of this small pilot study were to explore the association between premenstrual symptom severity and two genes from the gamma-aminobutyric acid (GABA) pathway: steroid-5-alpha-reductase, alpha polypeptide 1 (SRD5A1) and gamma-aminobutyric acid receptor subunit alpha-4 (GABRA4). Saliva samples were obtained from a convenience sample of 19 Caucasian females ages 18-25 years, ten cases and nine controls. Deoxyribonucleic acid (DNA) was isolated, and genotyping performed on ten single nucleotide polymorphisms (SNPs). Ten percent of cases and 44% of controls had the cytosine/cytosine (C/C) genotype for the SRD5A1 SNP, rs501999 indicating that this genotype may protect women against severe premenstrual symptoms. Replication of this study using an adequately powered sample size is warranted. |
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Authors:
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Marlene Adams; Susan McCrone |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Issues in mental health nursing Volume: 33 ISSN: 1096-4673 ISO Abbreviation: Issues Ment Health Nurs Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7907126 Medline TA: Issues Ment Health Nurs Country: England |
Other Details:
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Languages: eng Pagination: 101-8 Citation Subset: N |
Affiliation:
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University of Delaware, School of Nursing, Newark, Delaware, USA. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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