| SQUID-detected magnetic resonance imaging in microtesla fields. | |
| | |
MedLine Citation:
|
PMID: 17328671 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The use of very low noise magnetometers based on Superconducting QUantum Interference Devices (SQUIDs) enables nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) in microtesla magnetic fields. An untuned superconducting flux transformer coupled to a SQUID achieves a magnetic field noise of 10(-15) T Hz(-1/2). The frequency-independent response of this magnetometer combined with prepolarization of the nuclear spins yields an NMR signal that is independent of the Larmor frequency omega0. An MRI system operating in a field of 132 microT, corresponding to a proton frequency of 5.6 kHz, achieves an in-plane resolution of 0.7 x 0.7 mm2 in phantoms. Measurements of the longitudinal relaxation time T1 in different concentrations of agarose gel over five decades of frequency reveal much greater T1-differentiation at fields below a few millitesla. Microtesla MRI has the potential to image tumors with substantially greater T1-weighted contrast than is achievable in high fields in the absence of a contrast agent. |
| | |
Authors:
|
John Clarke; Michael Hatridge; Michael Mössle |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
|
Title: Annual review of biomedical engineering Volume: 9 ISSN: 1523-9829 ISO Abbreviation: Annu Rev Biomed Eng Publication Date: 2007 |
Date Detail:
|
Created Date: 2007-07-26 Completed Date: 2007-10-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883581 Medline TA: Annu Rev Biomed Eng Country: United States |
Other Details:
|
Languages: eng Pagination: 389-413 Citation Subset: IM |
Affiliation:
|
Department of Physics, University of California, Berkeley, California 94720-7300, USA. jclarke@berkeley.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Computer Simulation Equipment Design Image Enhancement / instrumentation*, methods Image Interpretation, Computer-Assisted / instrumentation*, methods Magnetic Resonance Imaging / instrumentation*, methods Magnetics / diagnostic use*, instrumentation* Models, Biological* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: HIV-1 Vpr potently induces programmed cell death in the CNS in vivo.
Next Document: Mechanisms of food intake repression in indispensable amino acid deficiency.