Document Detail

SPECT versus planar gated blood pool imaging for left ventricular evaluation.
MedLine Citation:
PMID:  17679063     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We developed a new segmentation algorithm based on the invariance of the Laplacian (IL) to compute volumes and ejection fractions and compared these results with planar analysis and gradients by use of a standard algorithm (QBS). METHODS AND RESULTS: Planar and single photon emission computed tomography blood pool acquisition was performed in 202 patients. Planar left ventricular ejection fraction (LVEF) was used as the gold standard, and single photon emission computed tomography images were processed by both 3-dimensional (3D) methods. Correlations between each 3D algorithm and planar methodology were as follows: r = 0.77 for QBS and r = 0.84 for IL. Mean LVEFs were 32.72% +/- 13.05% for the planar method, 32.32% +/- 15.98% for QBS, and 31.93% +/- 13.44% for IL (P = .16). Bland-Altman analysis closely demonstrated negligible systematic bias for both 3D methods. Standard errors of bias were comparable between methods (9.36% for QBS and 7.44% for IL, P = .48). Linear regression of the Bland-Altman bias revealed a slope significantly different from 0 for the QBS method (0.22 +/- 0.048, P < .0001) but not for IL (-0.032 +/- 0.0044, P = .47). CONCLUSION: The new segmentation algorithm provides comparable results to QBS and planar analysis. However, with QBS, the difference in LVEF was correlated with the magnitude of LVEF, which was not found with the new algorithm.
François Harel; Vincent Finnerty; Quam Ngo; Jean Grégoire; Paul Khairy; Bernard Thibault
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Publication Detail:
Type:  Journal Article     Date:  2007-06-27
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  14     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-08-06     Completed Date:  2007-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  544-9     Citation Subset:  IM    
Department of Nuclear Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
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MeSH Terms
Blood Pressure
Gated Blood-Pool Imaging / methods*
Imaging, Three-Dimensional
Middle Aged
Models, Statistical
Reproducibility of Results
Tomography, Emission-Computed, Single-Photon / methods*
Ventricular Dysfunction, Left / diagnosis*,  radionuclide imaging*
Ventricular Function, Left

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