| SPECT images of technetium-99m-ethyl cysteinate dimer in cerebrovascular diseases: comparison with other cerebral perfusion tracers and PET. | |
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MedLine Citation:
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PMID: 8271056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess the clinical role of 99mTc-ethyl cysteinate dimer (ECD) as a cerebral perfusion tracer, 10 patients with unilateral cerebral infarction were studied. METHODS: ECD SPECT images were compared with IMP and/or HMPAO SPECT in nine patients, seven in chronic phases and two in subacute phases. Five of these patients and one additional patient with chronic infarction received PET imaging in order to compare ECD distribution with quantitative regional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO2) images. RESULTS: In patients with chronic cerebral infarction, regression analysis showed excellent correlation between ECD and IMP in the uptake ratio of lesions-to-nonaffected cortices (r = 0.91). In two cases of subacute infarction, decreased uptake of ECD was observed in the area of "luxury perfusion," which showed elevated or preserved rCBF with diminished rCMRO2. On visual analysis, ECD image contrast was less prominent compared to that of IMP, but contrast was better than that of HMPAO. CONCLUSIONS: ECD uptake showed a curvilinear relationship against rCBF, suggesting flow-limited uptake in a high flow range. ECD is a clinically useful cerebral perfusion tracer with distinct characteristics when compared with other available agents. |
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Authors:
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T Tsuchida; S Nishizawa; Y Yonekura; N Sadato; Y Iwasaki; T Fujita; N Matoba; Y Magata; N Tamaki; J Konishi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 35 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-02-03 Completed Date: 1994-02-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 27-31 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Kyoto University Faculty of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amphetamines / diagnostic use Brain / radionuclide imaging Cerebral Infarction / physiopathology, radionuclide imaging* Cerebrovascular Circulation* Contrast Media Cysteine* / analogs & derivatives* Female Humans Iodine Radioisotopes / diagnostic use Iofetamine Male Middle Aged Organotechnetium Compounds / diagnostic use* Oximes / diagnostic use Technetium Tc 99m Exametazime Tomography, Emission-Computed* Tomography, Emission-Computed, Single-Photon* |
| Chemical | |
Reg. No./Substance:
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0/Amphetamines; 0/Contrast Media; 0/Iodine Radioisotopes; 0/Organotechnetium Compounds; 0/Oximes; 0/technetium Tc 99m bicisate; 100504-35-6/Technetium Tc 99m Exametazime; 52-90-4/Cysteine; 95896-48-3/Iofetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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