Document Detail

SOLVE and RESOLVE: automated structure solution and density modification.
MedLine Citation:
PMID:  14696367     Owner:  NLM     Status:  MEDLINE    
SOLVE and RESOLVE have shown that it is possible to automate a significant part of the macromolecular X-ray structure determination process. The key elements of seamless and compatible subprograms, scoring algorithms, and error-tolerant software systems have been important in implementing these programs. The principles used in SOLVE and RESOLVE can be applied to other aspects of structure determination as well, suggesting that full automation of the entire structure determination process from scaling diffraction data to a refined model will be possible in the near future.
Thomas C Terwilliger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in enzymology     Volume:  374     ISSN:  0076-6879     ISO Abbreviation:  Meth. Enzymol.     Publication Date:  2003  
Date Detail:
Created Date:  2003-12-30     Completed Date:  2004-02-04     Revised Date:  2009-07-24    
Medline Journal Info:
Nlm Unique ID:  0212271     Medline TA:  Methods Enzymol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-37     Citation Subset:  IM    
Los Alamos National Laboratory, Los Alamos, New Mexico 87545.
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MeSH Terms
Computational Biology / methods*
Crystallography, X-Ray / methods,  statistics & numerical data*
Data Interpretation, Statistical*
Peptide Initiation Factors / chemistry
RNA-Binding Proteins*
Reg. No./Substance:
0/Peptide Initiation Factors; 0/RNA-Binding Proteins; 0/eukaryotic translation initiation factor 5A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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