Document Detail


SOLVE and RESOLVE: automated structure solution and density modification.
MedLine Citation:
PMID:  14696367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SOLVE and RESOLVE have shown that it is possible to automate a significant part of the macromolecular X-ray structure determination process. The key elements of seamless and compatible subprograms, scoring algorithms, and error-tolerant software systems have been important in implementing these programs. The principles used in SOLVE and RESOLVE can be applied to other aspects of structure determination as well, suggesting that full automation of the entire structure determination process from scaling diffraction data to a refined model will be possible in the near future.
Authors:
Thomas C Terwilliger
Related Documents :
16873527 - Contrafold: rna secondary structure prediction without physics-based models.
20665277 - 3d structural models of transmembrane proteins.
10338017 - The calorimetric criterion for a two-state process revisited.
9565757 - Cooperativity in protein folding: from lattice models with sidechains to real proteins.
21092947 - Bias correction by use of errors-in-variables regression models in studies with k-x-ray...
25222717 - An improved parent-centric mutation with normalized neighborhoods for inducing niching ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in enzymology     Volume:  374     ISSN:  0076-6879     ISO Abbreviation:  Meth. Enzymol.     Publication Date:  2003  
Date Detail:
Created Date:  2003-12-30     Completed Date:  2004-02-04     Revised Date:  2009-07-24    
Medline Journal Info:
Nlm Unique ID:  0212271     Medline TA:  Methods Enzymol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-37     Citation Subset:  IM    
Affiliation:
Los Alamos National Laboratory, Los Alamos, New Mexico 87545.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Algorithms
Computational Biology / methods*
Crystallography, X-Ray / methods,  statistics & numerical data*
Data Interpretation, Statistical*
Peptide Initiation Factors / chemistry
RNA-Binding Proteins*
Software*
Chemical
Reg. No./Substance:
0/Peptide Initiation Factors; 0/RNA-Binding Proteins; 0/eukaryotic translation initiation factor 5A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Defined conditions for neural commitment and differentiation.
Next Document:  GRASP2: visualization, surface properties, and electrostatics of macromolecular structures and seque...