| SOLAR ultraviolet radiation and vitamin D: a historical perspective. | |
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MedLine Citation:
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PMID: 17761571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rickets, the state of vitamin D deficiency, has reemerged as a potential problem in the United States. At the dawn of the 20th century, rickets was pervasive among infants residing in the polluted cities of Europe and the northeastern United States. Important milestones in the history of rickets were the understanding that photosynthesized vitamin D and dietary vitamin D were similar, the discernment of the antirachitic potency of artificial and natural ultraviolet rays, and the discovery that ultraviolet irradiation could render various foods antirachitic. Clinical guidelines were instituted to promote sensible exposure to sunlight and artificial ultraviolet radiation. In addition, irradiated ergosterol from yeast became the major vitamin D source for food fortification and the treatment of rickets, leading to a public health campaign to eradicate rickets by the 1930s. We review the sequence and turn of events pertaining to the discovery of vitamin D and the strategies for the eradication of the reemerging rickets problem. |
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Authors:
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Kumaravel Rajakumar; Susan L Greenspan; Stephen B Thomas; Michael F Holick |
Publication Detail:
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Type: Historical Article; Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2007-08-29 |
Journal Detail:
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Title: American journal of public health Volume: 97 ISSN: 1541-0048 ISO Abbreviation: Am J Public Health Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-26 Completed Date: 2007-10-09 Revised Date: 2010-09-15 |
Medline Journal Info:
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Nlm Unique ID: 1254074 Medline TA: Am J Public Health Country: United States |
Other Details:
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Languages: eng Pagination: 1746-54 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pa 15213, USA. kumaravel.rajakumar@chp.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bone Density Conservation Agents
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history*,
therapeutic use History, 17th Century History, 18th Century History, 19th Century History, 20th Century Humans Rickets / drug therapy, history*, prevention & control Ultraviolet Therapy / history* United States Vitamin D / history*, therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
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P60 MD000207/MD/NCMHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bone Density Conservation Agents; 1406-16-2/Vitamin D |
| Comments/Corrections | |
Erratum In:
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Am J Public Health. 2007 Dec;97(12):2121 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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