| An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese. | |
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MedLine Citation:
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PMID: 22355539 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45-0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations. |
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Authors:
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Guoliang Zhang; Xinchun Chen; Long Chan; Mingxia Zhang; Baohua Zhu; Lantian Wang; Xiuyun Zhu; Jieyun Zhang; Boping Zhou; Junwen Wang |
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Publication Detail:
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Type: Journal Article Date: 2011-06-21 |
Journal Detail:
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Title: Scientific reports Volume: 1 ISSN: 2045-2322 ISO Abbreviation: Sci Rep Publication Date: 2011 |
Date Detail:
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Created Date: 2012-02-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101563288 Medline TA: Sci Rep Country: England |
Other Details:
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Languages: eng Pagination: 20 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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