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An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese.
MedLine Citation:
PMID:  22355539     Owner:  NLM     Status:  In-Data-Review    
Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45-0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations.
Guoliang Zhang; Xinchun Chen; Long Chan; Mingxia Zhang; Baohua Zhu; Lantian Wang; Xiuyun Zhu; Jieyun Zhang; Boping Zhou; Junwen Wang
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Publication Detail:
Type:  Journal Article     Date:  2011-06-21
Journal Detail:
Title:  Scientific reports     Volume:  1     ISSN:  2045-2322     ISO Abbreviation:  Sci Rep     Publication Date:  2011  
Date Detail:
Created Date:  2012-02-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101563288     Medline TA:  Sci Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  20     Citation Subset:  -    
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