Document Detail


SNP identification and polymorphism analysis in exon 2 of the horse myostatin gene.
MedLine Citation:
PMID:  22404361     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The myostatin gene (MSTN) belongs to the TGF-β superfamily of secreted growth and differentiation factors and is responsible for embryonic and adult skeletal muscle development. In this study, exon 2 of the MSTN gene, which encodes part of the TGF-β pro-peptide, was sequenced in 332 horses of 20 different breeds and compared with the horse MSTN gene sequence deposited in GenBank. The sequences obtained revealed the presence of 11 haplotypes represented by 10 variable nucleotide mutations, eight of them corresponding to amino acid sequence changes. This gene shows a high variability when compared with other genes. This might be an indication that some breeds have the same ancestry but different pressures of selection.
Authors:
E E Baron; M S Lopes; D Mendonça; A da Câmara Machado
Publication Detail:
Type:  Journal Article     Date:  2011-07-22
Journal Detail:
Title:  Animal genetics     Volume:  43     ISSN:  1365-2052     ISO Abbreviation:  Anim. Genet.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8605704     Medline TA:  Anim Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  229-32     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors, Animal Genetics © 2011 Stichting International Foundation for Animal Genetics.
Affiliation:
Biotechnology Centre of Azores, Department of Agriculture, University of Azores, Rua Capitão João D'Ávila, São Pedro, 9700-042 Angra do Heroísmo, Portugal.
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