| SMC proteins and chromosome structure. | |
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MedLine Citation:
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PMID: 9854313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The structure of chromosomes is largely determined by chromosome-associated proteins. Members of the SMC (structural maintenance of chromosomes) family play an important role in both prokaryotic and eukaryotic chromosome structure and dynamics. SMC proteins are involved in chromosome condensation, sister-chromatid cohesion, sex-chromosome dosage compensation, genetic recombination and DNA repair. There have been major advances recently in understanding the function of SMC proteins--including the identification of biochemical activities of SMC-containing protein complexes and the realization that individual SMC proteins might link seemingly unrelated aspects of chromosomal metabolism. |
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Authors:
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A V Strunnikov |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Trends in cell biology Volume: 8 ISSN: 0962-8924 ISO Abbreviation: Trends Cell Biol. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-03-22 Completed Date: 1999-03-22 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9200566 Medline TA: Trends Cell Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 454-9 Citation Subset: IM |
Affiliation:
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NIH, NICHD, Laboratory of Molecular Embryology, Unit of Chromosome Structure and Function, Bethesda, MD 20892, USA. strunnik@box-s.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carrier Proteins / chemistry, physiology* Cell Cycle Proteins / chemistry, physiology* Chromosomal Proteins, Non-Histone* DNA / biosynthesis Dosage Compensation, Genetic Fungal Proteins / chemistry, physiology* Mitosis Nuclear Proteins / chemistry, physiology* Protein Conformation Saccharomyces cerevisiae Proteins* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Cell Cycle Proteins; 0/Chromosomal Proteins, Non-Histone; 0/Fungal Proteins; 0/Nuclear Proteins; 0/SMC2 protein, S cerevisiae; 0/Saccharomyces cerevisiae Proteins; 0/structural maintenance of chromosome protein 1; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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