| SLE and pregnancy: the potential role for regulatory T cells. | |
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MedLine Citation:
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PMID: 20736925 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that disproportionally affects women, especially in their reproductive years. SLE is associated with considerable pregnancy-related morbidity-including fetal loss, preterm birth, fetal growth restriction and pre-eclampsia. CD4(+)CD25(+) regulatory T (T(REG)) cells have a potent immunosuppressive function and contribute to immunological self-tolerance. These cells might be essential for successful placental development by ensuring fetal tolerance. The numbers of T(REG) cells are augmented during normal pregnancy and, conversely, diminished numbers are associated with pregnancy loss and pre-eclampsia. Several studies have shown that patients with SLE have decreased numbers of T(REG) cells that might be functionally defective. This defective T(REG) cell functioning could predispose women with SLE to pregnancy complications. This article provides an overview of current knowledge of the role and function of T(REG) cells in SLE and pregnancy and how these cells might contribute to improving pregnancy-related outcomes in patients with SLE in the future. |
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Authors:
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Clare Tower; Ian Crocker; Debora Chirico; Philip Baker; Ian Bruce |
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Publication Detail:
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Type: Journal Article Date: 2010-08-24 |
Journal Detail:
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Title: Nature reviews. Rheumatology Volume: 7 ISSN: 1759-4804 ISO Abbreviation: Nat Rev Rheumatol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101500080 Medline TA: Nat Rev Rheumatol Country: United States |
Other Details:
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Languages: eng Pagination: 124-8 Citation Subset: IM |
Affiliation:
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Maternal and Fetal Health Research Center. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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