Document Detail


SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts.
MedLine Citation:
PMID:  24638860     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
KEY MESSAGES: Cigarette smoke induces pro-inflammatory and matrix-destructive responses in RASF. Cigarette smoke enhances the expression of SIRT6 in vitro and in vivo. TNFα increases the levels of SIRT6. SIRT6 diminishes MMP1 production under cigarette smoke extract and TNFα stimulation.
Authors:
Anna Engler; Fabienne Niederer; Kerstin Klein; Renate E Gay; Diego Kyburz; Giovanni G Camici; Steffen Gay; Caroline Ospelt
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-19
Journal Detail:
Title:  Journal of molecular medicine (Berlin, Germany)     Volume:  -     ISSN:  1432-1440     ISO Abbreviation:  J. Mol. Med.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504370     Medline TA:  J Mol Med (Berl)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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