| SIRT6 Puts Cancer Metabolism in the Driver's Seat. | |
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MedLine Citation:
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PMID: 23217699 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The rewiring of metabolism in cancer is thought to result from hyperactivation of signaling pathways that instruct cells to grow. Sebastian et al. show that loss of the tumor suppressor SIRT6 transforms cells by activating tumor metabolism. This occurs independently of mutations in canonical growth signaling pathways and reveals a tumorigenic role for cancer metabolism. |
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Authors:
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Costas A Lyssiotis; Lewis C Cantley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cell Volume: 151 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 1155-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Signal Transduction, Division of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Cornell Weill Medical College, New York, NY 10065, USA. Electronic address: clyssiot@bidmc.harvard.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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