Document Detail


SIRT6 puts cancer metabolism in the driver's seat.
MedLine Citation:
PMID:  23217699     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The rewiring of metabolism in cancer is thought to result from hyperactivation of signaling pathways that instruct cells to grow. Sebastian et al. show that loss of the tumor suppressor SIRT6 transforms cells by activating tumor metabolism. This occurs independently of mutations in canonical growth signaling pathways and reveals a tumorigenic role for cancer metabolism.
Authors:
Costas A Lyssiotis; Lewis C Cantley
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Cell     Volume:  151     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-02-06     Revised Date:  2013-09-02    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1155-6     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Signal Transduction, Division of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA. clyssiot@bidmc.harvard.edu
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 GM056203/GM/NIGMS NIH HHS
Comments/Corrections
Comment On:
Cell. 2012 Dec 7;151(6):1185-99   [PMID:  23217706 ]

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