| SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis. | |
| | |
MedLine Citation:
|
PMID: 21059157 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
We previously reported that sirtuin 2 (SIRT2), a mammalian member of the NAD+-dependent protein deacetylases, participates in mitotic regulation, specifically, in efficient mitotic cell death caused by the spindle checkpoint. Here, we describe a novel function of SIRT2 that is different from mitotic regulation. SIRT2 down-regulation using siRNA caused apoptosis in cancer cell lines such as HeLa cells, but not in normal cells. The apoptosis was caused by p53 accumulation, which is mediated by p38 MAPK activation-dependent degradation of p300 and the subsequent MDM2 degradation. Sirtuin inhibitors are emerging as antitumor drugs, and this function has been ascribed to the inhibition of SIRT1, the most well-characterized sirtuin that deacetylases p53 to promote cell survival and also binds to other proteins in response to genotoxic stress. This study suggests that SIRT2 can be a novel molecular target for cancer therapy and provides a molecular basis for the efficacy of SIRT2 for future cancer therapy. |
| | |
Authors:
|
Yanze Li; Haruka Matsumori; Yuji Nakayama; Mitsuhiko Osaki; Hirotada Kojima; Akihiro Kurimasa; Hisao Ito; Seiichi Mori; Motonobu Katoh; Mitsuo Oshimura; Toshiaki Inoue |
Related Documents
:
|
19226377 - Apoptosis in experimental nash is associated with p53 activation and trail receptor exp... 20048077 - Sodium orthovanadate inhibits p53-mediated apoptosis. 8709247 - Adenovirus type 5 early region 4 is responsible for e1a-induced p53-independent apoptosis. 12324477 - Cd27 and cd40 inhibit p53-independent mitochondrial pathways in apoptosis of b cells in... 17926337 - Anti-acne activity of selaginella involvens extract and its non-antibiotic antimicrobia... 21925117 - Defective dendritic cell generation from monocytes is a potential reason for poor thera... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-09 |
Journal Detail:
|
Title: Genes to cells : devoted to molecular & cellular mechanisms Volume: 16 ISSN: 1365-2443 ISO Abbreviation: Genes Cells Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-04 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9607379 Medline TA: Genes Cells Country: England |
Other Details:
|
Languages: eng Pagination: 34-45 Citation Subset: IM |
Copyright Information:
|
© 2010 The Authors. Journal compilation © 2010 by the Molecular Biology Society of Japan/Blackwell Publishing Ltd. |
Affiliation:
|
Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rolling circle replication of human papillomavirus type 16 DNA in epithelial cell extracts.
Next Document: Campylobacter genotypes from poultry transportation crates indicate a source of contamination and tr...