Document Detail

SIDS pathogenesis: pathological findings indicate infection and inflammatory responses are involved.
MedLine Citation:
PMID:  15325393     Owner:  NLM     Status:  MEDLINE    
This article explores the pathological evidence that supports the hypothesis that infection and inflammation are underlying mechanisms in SIDS. It reviews the pathological findings in relation to the risk factors reported for SIDS and compares these findings with other hypotheses suggested as causes of these unexplained deaths in infants. The roles of environmental factors and bacterial products such as soluble curlin detectable in SIDS sera in triggering cytokine cascades and aberrant inflammatory responses resulting in a toxic shock-like event are also explored. Areas for future research are outlined.
Paul N Goldwater
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  FEMS immunology and medical microbiology     Volume:  42     ISSN:  0928-8244     ISO Abbreviation:  FEMS Immunol. Med. Microbiol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-24     Completed Date:  2004-10-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9315554     Medline TA:  FEMS Immunol Med Microbiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  11-20     Citation Subset:  IM    
Department of Microbiology and Infectious Diseases, The Womens and Children's Hospital, North Adelaide 5006, Australia.
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MeSH Terms
Infant, Newborn
Infection / complications*
Inflammation / complications*
Sudden Infant Death / etiology,  pathology*

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