Document Detail

Microbial ecology and host-microbiota interactions during early life stages.
MedLine Citation:
PMID:  22743759     Owner:  NLM     Status:  MEDLINE    
The role of human microbiota has been redefined during recent years and its physiological role is now much more important than earlier understood. Intestinal microbial colonization is essential for the maturation of immune system and for the developmental regulation of the intestinal physiology. Alterations in this process of colonization have been shown to predispose and increase the risk to disease later in life. The first contact of neonates with microbes is provided by the maternal microbiota. Moreover, mode of delivery, type of infant feeding and other perinatal factors can influence the establishment of the infant microbiota. Taken into consideration all the available information it could be concluded that the exposure to the adequate microbes early in gestation and neonatal period seems to have a relevant role in health. Maternal microbial environment affects maternal and fetal immune physiology and, of relevance, this interaction with microbes at the fetal-maternal interface could be modulated by specific microbes administered to the pregnant mother. Indeed, probiotic interventions aiming to reduce the risk of immune-mediated diseases may appear effective during early life.
Maria Carmen Collado; Maria Cernada; Christine Baüerl; Máximo Vento; Gaspar Pérez-Martínez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-06-29
Journal Detail:
Title:  Gut microbes     Volume:  3     ISSN:  1949-0984     ISO Abbreviation:  Gut Microbes     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-09-19     Completed Date:  2013-01-28     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101495343     Medline TA:  Gut Microbes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352-65     Citation Subset:  IM    
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MeSH Terms
Gastrointestinal Tract / microbiology*
Immune System / physiology*
Infant, Newborn
Erratum In:
Gut Microbes. 2014 Mar-Apr;5(2):271-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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