Document Detail


The SHORT-ROOT protein acts as a mobile, dose-dependent signal in patterning the ground tissue.
MedLine Citation:
PMID:  22826238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A key question in developmental biology is how cellular patterns are created and maintained. During the formation of the Arabidopsis root, the endodermis, middle cortex (MC), and cortex are produced by periclinal cell divisions that occur at different positions and at different times in root development. The endodermis and cortex arise continuously from the periclinal divisions of cells that surround the quiescent center (QC) at the tip of the root. The MC arises between days 7 and 14 from periclinal divisions of the endodermis. The divisions that produce the middle cortex begin in the basal region of the root meristem away from the QC and then spread apically and circumferentially around the root. Although the transcription factor SHORT-ROOT (SHR) is required for both of these divisions, the mechanism that determines where and when SHR acts to promote cell division along the longitudinal axis of the root is unknown; SHR is present along the entire length of the root tip, but only promotes periclinal divisions at specific sites. Here we show that the abundance of the SHR protein changes dynamically as the root develops, and that the pattern of cell division within the endodermis is sensitive to the dose of this protein: high levels of SHR prevent the formation of the MC, whereas intermediate levels of SHR promote MC formation. These results provide a mechanism for the longitudinal patterning of the endodermis, and represent the first example in plants of a mobile transcription factor whose function (activator or repressor) depends upon concentration.
Authors:
Koji Koizumi; Tomomi Hayashi; Shuang Wu; Kimberly L Gallagher
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-07-23
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-08     Completed Date:  2012-10-15     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13010-5     Citation Subset:  IM    
Affiliation:
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
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MeSH Terms
Descriptor/Qualifier:
Arabidopsis / embryology*,  genetics
Arabidopsis Proteins / metabolism*
Body Patterning / genetics*
Cell Division / genetics,  physiology
Crosses, Genetic
Gene Expression Regulation, Developmental / genetics,  physiology*
Gene Expression Regulation, Plant / genetics,  physiology*
Microscopy, Confocal
Plant Roots / cytology,  embryology*
Plants, Genetically Modified
Polymerase Chain Reaction
Transcription Factors / metabolism*
Chemical
Reg. No./Substance:
0/Arabidopsis Proteins; 0/SHORT ROOT protein, Arabidopsis; 0/Transcription Factors
Comments/Corrections

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