| SGLT2 inhibition--a novel strategy for diabetes treatment. | |
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MedLine Citation:
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PMID: 20508640 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inhibiting sodium-glucose co-transporters (SGLTs), which have a key role in the reabsorption of glucose in the kidney, has been proposed as a novel therapeutic strategy for diabetes. Genetic mutations in the kidney-specific SGLT2 isoform that result in benign renal glycosuria, as well as preclinical and clinical studies with SGLT2 inhibitors in type 2 diabetes, support the potential of this approach. These investigations indicate that elevating renal glucose excretion by suppressing SGLT2 can reduce plasma glucose levels, as well as decrease weight. Although data from ongoing Phase III trials of these agents are needed to more fully assess safety, results suggest that the beneficial effects of SGLT2 inhibition might be achieved without exerting significant side effects--an advantage over many current diabetes medications. This article discusses the role of SGLT2 in glucose homeostasis and the evidence available so far on the therapeutic potential of blocking these transporters in the treatment of diabetes. |
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Authors:
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Edward C Chao; Robert R Henry |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2010-05-28 |
Journal Detail:
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Title: Nature reviews. Drug discovery Volume: 9 ISSN: 1474-1784 ISO Abbreviation: Nat Rev Drug Discov Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124171 Medline TA: Nat Rev Drug Discov Country: England |
Other Details:
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Languages: eng Pagination: 551-9 Citation Subset: IM |
Affiliation:
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Section of Endocrinology, Metabolism and Diabetes, VA San Diego Healthcare System and University of California, San Diego School of Medicine, 3350 La Jolla Village Drive, 111 G San Diego, California 92161, USA. edward.chao@va.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus / drug therapy* Diabetes Mellitus, Type 2 / drug therapy Drug Design Glucose / metabolism Humans Hypoglycemic Agents / adverse effects, pharmacology*, therapeutic use* Kidney / metabolism Oligonucleotides, Antisense / therapeutic use Sodium-Glucose Transporter 2 / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 0/Oligonucleotides, Antisense; 0/SLC5A2 protein, human; 0/Sodium-Glucose Transporter 2; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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