| SERCA2a and mitochondrial cytochrome oxidase expression are increased in hearts of exercise-trained old rats. | |
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MedLine Citation:
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PMID: 8760159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aging of rats results in slower activities of calcium transport by cardiac calcium adenosinetriphosphatase (ATPase) of the sarcoplasmic reticulum (SR) and mitochondrial cytochrome oxidase (COX). These enzyme activities are faster after exercise training of previously sedentary old rats. Our purpose was to determine whether the expression of the genes encoding SR calcium ATPase (SERCA2a) or COX is altered by exercise training. Old (24-mo-old) male Fischer 344 rats were assigned to SO (sedentary old) or EO (exercised old) groups and compared with younger (12-mo-old) sedentary rats (SM). EO rats were trained on a treadmill for 8-10 wk. SERCA2a and COX mRNAs were lower (P < 0.05) in SO compared with SM and EO, whereas glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and cardiac alpha-actin mRNAs were similar across groups. The immunoreactive protein contents of cardiac calcium ATPase, cytochrome c, sarcomeric actin, and GAPDH followed the changes, when observed, in mRNA contents. Thus pretranslational mechanisms may be modified in some genes during aging and exercise training of previously sedentary old rats. |
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Authors:
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C A Tate; T Helgason; M F Hyek; R P McBride; M Chen; M A Richardson; G E Taffet |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 271 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-10-08 Completed Date: 1996-10-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H68-72 Citation Subset: IM |
Affiliation:
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Department of Pharmacological and Pharmaceutical Sciences, University of Houston 77204-5515, Texas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Calcium-Transporting ATPases / genetics, metabolism* Electron Transport Complex IV / genetics, metabolism* Homeostasis Male Mitochondria, Heart / enzymology* Myocardium / enzymology* Physical Conditioning, Animal* RNA, Messenger / metabolism Rats Rats, Inbred F344 Sarcoplasmic Reticulum / enzymology* |
| Grant Support | |
ID/Acronym/Agency:
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AG-06221/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; EC 1.9.3.1/Electron Transport Complex IV; EC 3.6.1.8/Calcium-Transporting ATPases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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