| SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation. | |
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MedLine Citation:
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PMID: 22028379 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Transcription factor IRF3-mediated type I interferon induction is essential for antiviral innate immunity. We identified the deSUMOylating enzyme Sentrin/SUMO-specific protease (SENP) 2 as a negative regulator of virus-triggered IFN-β induction. Overexpression of SENP2 caused IRF3 deSUMOylation, K48-linked ubiquitination, and degradation, whereas depletion of SENP2 had opposite effects. Both the SUMOylation and K48-linked ubiquitination of IRF3 occurred at lysines 70 and 87, and these processes are competitive. The level of virus-triggered IFN-β was markedly up-regulated and viral replication was reduced in SENP2-deficient cells comparing with wild-type controls. Our findings suggest that SENP2 regulates antiviral innate immunity by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation, and provide an example of cross-talk between the ubiquitin and SUMO pathways in innate immunity. |
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Authors:
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Yong Ran; Tian-Tian Liu; Qian Zhou; Shu Li; Ai-Ping Mao; Ying Li; Li-Juan Liu; Jin-Ke Cheng; Hong-Bing Shu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of molecular cell biology Volume: 3 ISSN: 1759-4685 ISO Abbreviation: J Mol Cell Biol Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101503669 Medline TA: J Mol Cell Biol Country: United States |
Other Details:
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Languages: eng Pagination: 283-92 Citation Subset: IM |
Affiliation:
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College of Life Sciences, Wuhan University, Wuhan 430072, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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