Document Detail


SENP1 protects against myocardial ischemia/reperfusion injury via a HIF1α-dependent pathway.
MedLine Citation:
PMID:  25082844     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIMS: SUMO-specific protease 1 (SENP1) removes SUMO from proteins and plays important roles in the regulation of multiple cellular signaling pathways. However, little is known about the role of SENP1 in coronary heart disease. In this study, we tested the hypothesis that SENP1 protects against myocardial ischemia/reperfusion (I/R) injury and investigated the underlying molecular mechanisms involved.
METHODS AND RESULTS: First, we found that SENP1 levels increased after I/R in human and mouse myocardium in vivo and in rat cardiomyocytes in vitro. We then performed coronary artery ligation to induce I/R injury in wild-type and heterozygous SENP1-knockdown (SENP1(+/-)) mice. Compared to wild-type mice, SENP1(+/-) mice had normal cardiac function at baseline but lower systolic function after I/R. Post-I/R myocardial infarction sizes were larger in SENP1(+/-) mice. Furthermore, we demonstrated that SENP1 regulates the expression of HIF1α, a critical protective factor during I/R, in vivo and in vitro. Overexpression of HIF1α reversed the deteriorating effect of SENP1 knockdown on cellular death.
CONCLUSIONS: Our results suggest that SENP1 deficiency exacerbates I/R injury in cardiomyocytes via a HIF1 α-dependent pathway.
Authors:
Jianmin Gu; Yuqi Fan; Xiaobing Liu; Lihuang Zhou; Jinke Cheng; Rong Cai; Song Xue
Related Documents :
15716284 - The initial management of stable angina in europe, from the euro heart survey: a descri...
24166314 - Omega 3 chronic supplementation attenuates myocardial ischaemia-reperfusion injury thro...
23698774 - The role of sulfur dioxide in the regulation of mitochondrion-related cardiomyocyte apo...
12393774 - Preoperative evaluation of patients with, or at risk of, coronary artery disease underg...
19088394 - Unusual case of left ventricular pseudoaneurysm.
11074964 - Xpose: a new device that provides reproducible and easy access for multivessel beating ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-31
Journal Detail:
Title:  Cardiovascular research     Volume:  -     ISSN:  1755-3245     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-8-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A PILOT STUDY EXAMINING THE EFFECTS OF TOLVAPTAN ON RESIDUAL RENAL FUNCTION IN PERITONEAL DIALYSIS F...
Next Document:  Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expressi...