Document Detail

A SEM analysis of DMSO treated hydra polyps.
MedLine Citation:
PMID:  7987246     Owner:  NLM     Status:  MEDLINE    
Scanning electron microscopy revealed that exposure of hydra polyps to DMSO at concentrations used for permeabilizing tissue results in striking changes in epithelial cell morphology. Epithelial cells from treated polyps rounded up in shape and formed numerous large blebs at the cell surface. Along the borders of epithelial cells numerous small projections became detectable. The DMSO-induced changes at the cell surface corresponded to drastic changes in the intracellular organization. No evidence could be found for DMSO induced opening of cell junctions and/or opening of the interstitial space. The results demonstrate that DMSO affects the morphology and intracellular organization of hydra epithelial cells. Thus, caution is necessary in interpreting cell behavior in DMSO treated tissue.
A Bolzer; R R Melzer; T C Bosch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the cell / under the auspices of the European Cell Biology Organization     Volume:  81     ISSN:  0248-4900     ISO Abbreviation:  Biol. Cell     Publication Date:  1994  
Date Detail:
Created Date:  1995-01-10     Completed Date:  1995-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8108529     Medline TA:  Biol Cell     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  83-6     Citation Subset:  IM    
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MeSH Terms
Dimethyl Sulfoxide / pharmacology*
Hydra / drug effects*,  ultrastructure
Microscopy, Electron, Scanning
Reg. No./Substance:
67-68-5/Dimethyl Sulfoxide

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