| SCORTEN and impaired renal function related to mortality of toxic epidermal necrolysis syndrome patients in the Asian population. | |
| | |
MedLine Citation:
|
PMID: 22452516 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background Toxic epidermal necrolysis syndrome (TEN) is a rare, life-threatening, drug-related skin reaction with a high mortality rate. To date, only a few studies with insufficient sample sizes have been conducted to analyse SCORTEN in Asian populations with TEN. Objective To analyse SCORTEN and other related factors that affect TEN patients in Taiwan. Methods A retrospective review of medical records of 101 patients with TEN from 1992 to 2009. Results There were 62 cases of adverse reactions to a single medication and 39 cases of idiopathic reaction, from multiple medications, or infectious pathogens, of 101 TEN patients. Of the seven individual SCORTEN parameters, only associate malignancy, detached or compromised body surface area >10%, serum urea and bicarbonate were statistically significant in the multivariate analysis. Factors such as 1.5 times baseline serum creatinine levels, urine output of less than 0.5 mL/kg for 6 h and acute renal failure were connected with subsequent mortality. Conclusion The SCORTEN score is effective in predicting the outcome in Taiwanese TEN patients. A number of factors are predictors of mortality. In our study, we determine renal insufficiency and failure to be a marker for predicting a poor outcome. |
| | |
Authors:
|
C-H Hu; N-J Chang; E K-W Liu; S-S Chuang; W-H Chung; J-Y Yang |
Related Documents
:
|
22402706 - Delayed preattentional functioning in early psychosis patients with cannabis use. 16491416 - The clinical features of anti-neutrophil cytoplasmic antibody-associated systemic vascu... 9475086 - Variants of alpha 1-proteinase inhibitor in black and white south african patients with... 6687796 - Urinary immune complexes in patients with glomerular diseases. their possible diagnosti... 3177566 - Course and outcome of ocular sarcoidosis. 21902146 - Neutral mechanical alignment: a requirement for successful tka: opposes. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-27 |
Journal Detail:
|
Title: Journal of the European Academy of Dermatology and Venereology : JEADV Volume: - ISSN: 1468-3083 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9216037 Medline TA: J Eur Acad Dermatol Venereol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology. |
Affiliation:
|
Lin Kou Burn Centre, the Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University, Taipei, Taiwan Department of Dermatology, Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University, Taipei, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Psychiatric Advance Directives as a complex and multistage intervention: a realist systematic review...
Next Document: Can a partial volume edge effect reduction algorithm improve the repeatability of subject-specific f...