| SCH 34826: an overview of its profile as a neutral endopeptidase inhibitor and ANF potentiator. | |
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MedLine Citation:
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PMID: 1835684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our studies with the prototypical NEP inhibitor SCH 34826 indicate the potential role of this class of compounds in cardiovascular modulation. The data assembled to date indicate that NEP inhibition elicits significant ANF-like effects in animals and man. The early data generated to date on SCH 34826, when considered with those data generated on other NEP inhibitors, indicate that NEP inhibition may have therapeutic utility in some forms of hypertension and congestive heart failure. |
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Authors:
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E J Sybertz |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical nephrology Volume: 36 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 1991 Oct |
Date Detail:
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Created Date: 1992-01-09 Completed Date: 1992-01-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 187-91 Citation Subset: IM |
Affiliation:
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Schering Plough Research, Bloomfield, New Jersey 07003. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / pharmacology* Atrial Natriuretic Factor* Dioxolanes / pharmacology* Dipeptides / pharmacology* Drug Synergism Heart Failure / drug therapy Humans Hypertension / drug therapy Neprilysin / antagonists & inhibitors* Prodrugs Rats |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Dioxolanes; 0/Dipeptides; 0/Prodrugs; 105262-04-2/Sch 34826; 83861-02-3/SCH 32615; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.24.11/Neprilysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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