| SC1, a brain extracellular matrix glycoprotein related to SPARC and follistatin, is expressed by rat cerebellar astrocytes following injury and during development. | |
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MedLine Citation:
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PMID: 8883893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the nervous system, extracellular matrix components are believed to influence cell shape, proliferation and migration during development and following injury. SC1 is a secreted glycoprotein expressed during neural development and in the adult brain. The molecule shows partial sequence homology to the anti-adhesive extracellular matrix molecule SPARC/osteonectin and to follistatin. We have made a surgical lesion in the adult rat cerebellum and examined changes in SC1 expression at 1 to 14 days after injury. Dual in situ hybridization/immunohistochemistry demonstrated that SC1 mRNA was induced in astrocytes surrounding the wound, reaching maximal levels at 10 days post-lesion. Immunohistochemistry revealed changes in the deposition of SC1 protein in radial fibres of Bergmann glia. SC1 protein was also detected at the border of the lesion, suggesting an association with the glial scar. Double immunohistochemistry with the astrocytic marker GFAP demonstrated that astrocytes also express SC1 during postnatal development. |
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Authors:
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D B Mendis; G O Ivy; I R Brown |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 730 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1997-01-28 Completed Date: 1997-01-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 95-106 Citation Subset: IM |
Affiliation:
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Department of Zoology, University of Toronto, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activated-Leukocyte Cell Adhesion Molecule Aging / metabolism* Animals Animals, Newborn / growth & development, metabolism* Astrocytes / metabolism* Blotting, Northern Cerebellar Diseases / metabolism*, pathology Cerebellum / cytology, metabolism*, pathology Extracellular Matrix Proteins / genetics, metabolism* Immunohistochemistry In Situ Hybridization Male Nerve Tissue Proteins / genetics, metabolism* RNA, Messenger / metabolism Rats Rats, Wistar Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Activated-Leukocyte Cell Adhesion Molecule; 0/Extracellular Matrix Proteins; 0/Nerve Tissue Proteins; 0/RNA, Messenger |
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