Document Detail


SASP gene delivery: a novel antibacterial approach.
MedLine Citation:
PMID:  19536364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antibiotic resistance is a global problem, and with bacteria having developed resistance to all approved antibacterial agents there is a growing need for innovative solutions. Phico Therapeutics has developed a new class of antibacterial agent, a platform technology called SASPject. SASPject comprises modified, disabled bacterial viruses (bacteriophages) injecting a gene encoding an antibacterial protein, SASP, into target bacteria. SASP, or Small, Acid-soluble Spore Protein(s), inactivate bacterial DNA in a non-sequence-specific manner so their activity is unaffected by DNA mutations. Selected pathogens can be targeted, avoiding the normal flora. A Staphylococcus aureus-targeted SASPject, PT1.2, developed for the nasal decolonization of S. aureus, including methicillin-resistant (MRSA) strains, is expected to complete phase I in 2009. SASPject PT1.2 shows good in vitro activity against a wide range of diverse clinical S. aureus isolates, including MRSA strains. A systemic SASPject PT1.2, and SASPjects targeted against Clostridium difficile and multidrug-resistant Gram-negative organisms are in development. The SASPject technology could represent a new paradigm in antibacterial therapeutics.
Authors:
Heather Fairhead
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug news & perspectives     Volume:  22     ISSN:  0214-0934     ISO Abbreviation:  Drug News Perspect.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-06-18     Completed Date:  2009-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809164     Medline TA:  Drug News Perspect     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  197-203     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Prous Science, S.A.U. or its licensors. All rights reserved.
Affiliation:
Phico Therapeutics Ltd., Babraham Research Campus, Cambridge, UK. hf@phicotherapeutics.co.uk
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology
Bacteria / drug effects,  genetics
Bacterial Proteins / genetics*
Bacteriophages / genetics*
Drug Resistance, Multiple, Bacterial / genetics
Gene Transfer Techniques*
Humans
Spores, Bacterial / genetics
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Bacterial Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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