Document Detail

[SAMHD1-- A HIV-1 restriction factor derived from Myeloid lineage monocytes].
MedLine Citation:
PMID:  23019037     Owner:  NLM     Status:  In-Data-Review    
HIV-1 restriction factors have became one of the hottest fields of AIDS researches. In 2011, SAMHD1 was demonstrated to be a novel HIV-1 restriction factor, adding to a list of HIV-1 restriction factors that include APOBEC3G, TRIM5α and Tetherin. SAMHD1 is highly expressed in myeloid-lineage monocytes, such as macrophages and dendritic cells. In this paper, we review the current research progress on the structure of SAMHD1, its antiviral mechanism, interaction with the lentivirus Vpx, and evolution. The identification of SAMHD1 opens the door towards understanding the role of SAMHD1 in lentiviral pathogenesis.
Pei-Lu Li; Qian-Qian Chen; Chi-Yu Zhang
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Dong wu xue yan jiu = Zoological research / "Dong wu xue yan jiu" bian ji wei yuan hui bian ji     Volume:  33     ISSN:  0254-5853     ISO Abbreviation:  Zool. Res.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100961499     Medline TA:  Dongwuxue Yanjiu     Country:  China    
Other Details:
Languages:  chi     Pagination:  537-41     Citation Subset:  IM    
Institute of Life Sciences, Jiangsu University, Zhenjiang Jiangsu 212013, China.
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