| S1P receptor mediated activity of FTY720 phosphate mimics. | |
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MedLine Citation:
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PMID: 20153186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Various carboxylic acids, phosphonic acids, sulfonic acids, tetrazoles as well as sulfonylhydantoins were prepared as phosphate mimics of the chiral aminophosphate 1-P to act as agonists on the S1P(1) receptor. It was found that amino phosphonates and amino carboxylates are potent S1P(1) binders. beta-Amino acid 11 could be shown to reversibly reduce blood lymphocyte counts in rats after po administration. |
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Authors:
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Klemens H?genauer; Klaus Hinterding; Peter Nussbaumer |
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Publication Detail:
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Type: Journal Article Date: 2010-01-28 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 20 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-22 Completed Date: 2010-05-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 1485-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland. klemens.hoegenauer@novartis.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Amino Acids / chemistry Animals Immunosuppressive Agents / chemical synthesis, chemistry*, pharmacology Isoleucine / analogs & derivatives*, chemical synthesis, chemistry, pharmacology Lymphocytes / drug effects, immunology Phosphates / chemistry* Phosphorylation Propylene Glycols / chemistry*, pharmacology Rats Receptors, Lysosphingolipid / agonists*, metabolism Sphingosine / analogs & derivatives*, chemistry, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Immunosuppressive Agents; 0/Phosphates; 0/Propylene Glycols; 0/Receptors, Lysosphingolipid; 123-78-4/Sphingosine; 162359-55-9/fingolimod; 73-32-5/Isoleucine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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