Document Detail


S1P receptor mediated activity of FTY720 phosphate mimics.
MedLine Citation:
PMID:  20153186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Various carboxylic acids, phosphonic acids, sulfonic acids, tetrazoles as well as sulfonylhydantoins were prepared as phosphate mimics of the chiral aminophosphate 1-P to act as agonists on the S1P(1) receptor. It was found that amino phosphonates and amino carboxylates are potent S1P(1) binders. beta-Amino acid 11 could be shown to reversibly reduce blood lymphocyte counts in rats after po administration.
Authors:
Klemens H?genauer; Klaus Hinterding; Peter Nussbaumer
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Publication Detail:
Type:  Journal Article     Date:  2010-01-28
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  20     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-05-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  1485-7     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland. klemens.hoegenauer@novartis.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Amino Acids / chemistry
Animals
Immunosuppressive Agents / chemical synthesis,  chemistry*,  pharmacology
Isoleucine / analogs & derivatives*,  chemical synthesis,  chemistry,  pharmacology
Lymphocytes / drug effects,  immunology
Phosphates / chemistry*
Phosphorylation
Propylene Glycols / chemistry*,  pharmacology
Rats
Receptors, Lysosphingolipid / agonists*,  metabolism
Sphingosine / analogs & derivatives*,  chemistry,  pharmacology
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Immunosuppressive Agents; 0/Phosphates; 0/Propylene Glycols; 0/Receptors, Lysosphingolipid; 123-78-4/Sphingosine; 162359-55-9/fingolimod; 73-32-5/Isoleucine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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