Document Detail


S1P Regulation of Macrophage Functions in The Context of Cancer.
MedLine Citation:
PMID:  21707489     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The sphingolipid sphingosine-1-phosphate (S1P) is an important regulator of immune cell functions in vivo. Besides recruiting lymphocytes to blood and lymph, it may promote immune cell survival and proliferation, but also interferes with their activation. Hereby, S1P may act as an intracellular second messenger or cofactor or, upon being secreted from cells, may bind to and activate a family of specific G-protein-coupled receptors (S1PR1-5). Extracellular versus intracellular S1P hereby might trigger synergistic/identical or fundamentally distinct responses. Furthermore, engagement of different S1PRs is connected to different functional outcome. This complexity is exemplified by the influence of S1P on the inflammatory potential of macrophages, shaping their role in inflammatory pathologies such as atherosclerosis and cancer. Here, we summarize the recent progress in understanding the impact of S1P signaling in macrophage biology, discuss its impact in solid as well as 'wet' tumors and elaborate potential options to interfere with S1P signaling in the context of cancer.
Authors:
Andreas Weigert; Benjamin Weichand; Bernhard Brüne
Related Documents :
21776409 - Regulation of toll and toll-like receptor signaling by the endocytic pathway.
45789 - Cellular aspects of conjunctival inflammation induced by the synergistic action of hist...
20443209 - Inhibitory effect of jeju endemic seaweeds on the production of pro-inflammatory mediat...
2999289 - Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin e2 production ...
11028559 - Blocking prostaglandin e2 after trauma attenuates pro-inflammatory cytokines and improv...
22094429 - Cellular ageing and the actin cytoskeleton.
22341799 - The distribution of immune cells in the lungs of classical and atypical ovine pulmonary...
20727039 - Differential b-lymphocyte regulation by cd40 and its viral mimic, latent membrane prote...
21113129 - Ros-mediated amplification of akt/mtor signalling pathway leads to myeloproliferative s...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-27
Journal Detail:
Title:  Anti-cancer agents in medicinal chemistry     Volume:  -     ISSN:  1875-5992     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265649     Medline TA:  Anticancer Agents Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany. bruene@pathobiochemie1.de.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ceramidases in Hematological Malignancies: Senseless Or Neglected Target?
Next Document:  Targeting sphingosine-1-phosphate receptors in cancer.