Document Detail


S179D prolactin: antagonistic agony!
MedLine Citation:
PMID:  17669587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aims of this review are three-fold: first, to collate what is known about the production and activities of phosphorylated prolactin (PRL), the latter largely, but not exclusively, as illustrated through the use of the molecular mimic, S179D PRL; second, to apply this and related knowledge to produce an updated model of prolactin-receptor interactions that may apply to other members of this cytokine super-family; and third, to promote a shift in the current paradigm for the development of clinically important growth antagonists. This third aim explains the title since, based on results with S179D PRL, it is proposed that agents which signal to antagonistic ends may be better therapeutics than pure antagonists-hence antagonistic agony. Since S179D PRL is not a pure antagonist, we have proposed the term selective prolactin receptor modulator (SPeRM) for this and like molecules.
Authors:
Ameae M Walker
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2007-06-28
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  276     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-07     Completed Date:  2007-12-13     Revised Date:  2014-11-10    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Ligands
Phosphorylation
Prolactin / antagonists & inhibitors*,  metabolism
Receptors, Cell Surface / metabolism
Grant Support
ID/Acronym/Agency:
DK 61005/DK/NIDDK NIH HHS; R01 DK061005/DK/NIDDK NIH HHS; R01 DK061005-04/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Ligands; 0/Receptors, Cell Surface; 0/prolactin, Asp(179)-; 9002-62-4/Prolactin
Comments/Corrections

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