| S100B protein in the gut: The evidence for enteroglial-sustained intestinal inflammation. | |
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MedLine Citation:
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PMID: 21455324 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Glial cells in the gut represent the morphological and functional equivalent of astrocytes and microglia in the central nervous system (CNS). In recent years, the role of enteric glial cells (EGCs) has extended from that of simple nutritive support for enteric neurons to that of being pivotal participants in the regulation of inflammatory events in the gut. Similar to the CNS astrocytes, the EGCs physiologically express the S100B protein that exerts either trophic or toxic effects depending on its concentration in the extracellular milieu. In the CNS, S100B overexpression is responsible for the initiation of a gliotic reaction by the release of pro-inflammatory mediators, which may have a deleterious effect on neighboring cells. S100B-mediated pro-inflammatory effects are not limited to the brain: S100B overexpression is associated with the onset and maintenance of inflammation in the human gut too. In this review we describe the major features of EGCs and S100B protein occurring in intestinal inflammation deriving from such. |
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Authors:
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Carla Cirillo; Giovanni Sarnelli; Giuseppe Esposito; Fabio Turco; Luca Steardo; Rosario Cuomo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 17 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 1261-6 Citation Subset: IM |
Affiliation:
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Carla Cirillo, Giovanni Sarnelli, Fabio Turco, Rosario Cuomo, Department of Clinical and Experimental Medicine, University of Naples "Federico II", Naples, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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