Document Detail

The S100B protein in biological fluids: more than a lifelong biomarker of brain distress.
MedLine Citation:
PMID:  22145907     Owner:  NLM     Status:  Publisher    
S100B is a calcium-binding protein concentrated in glial cells, although it has also been detected in definite extra-neural cell types. Its biological role is still debated. When secreted, S100B is believed to have paracrine/autocrine trophic effects at physiological concentrations, but toxic effects at higher concentrations. Elevated S100B levels in biological fluids (cerebrospinal fluid, blood, urine, saliva, amniotic fluid) are thus regarded as a biomarker of pathological conditions, including perinatal brain distress, acute brain injury, brain tumors, neuroinflammatory/neurodegenerative disorders, psychiatric disorders. In the majority of these conditions high S100B levels offer an indicator of cell damage when standard diagnostic procedures are still silent. The key question remains as to whether S100B is merely leaked from injured cells or is released in concomitance with both physiological and pathological conditions, participating at high concentrations in the events leading to cell injury. In this respect, S100B levels in biological fluids have been shown to increase in physiological conditions characterized by stressful physical and mental activity, suggesting that it may be physiologically regulated and raised during conditions of stress, with a putatively active role. This possibility makes this protein a candidate not only for a biomarker but also for a potential therapeutic target.
Fabrizio Michetti; Valentina Corvino; Maria Concetta Geloso; Wanda Lattanzi; Camilla Bernardini; Laura Serpero; Diego Gazzolo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-6
Journal Detail:
Title:  Journal of neurochemistry     Volume:  -     ISSN:  1471-4159     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Journal of Neurochemistry © 2011 International Society for Neurochemistry.
 Institute of Anatomy and Cell Biology, Università Cattolica Sacro Cuore, Largo F. Vito 1 - 00168 Roma, Italy  Department of Neurology, Ofthalmology and Genetics, Università di Genova, Via De Toni, 5 - 16132 Genova, Italy  Department of Maternal, Fetal and Neonatal Medicine, C. Arrigo Children's Hospital, Spalto Marengo 46 - 15100 Alessandria, Italy  Institute for Research on Mental Retardation and Brain Aging IRCCS Oasi di Troina, Troina, Via Conte Ruggero 73 94018 TROINA, Italy.
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