Document Detail


S100B protein expression in the heart of deceased individuals by overdose: a new forensic marker?
MedLine Citation:
PMID:  22892929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The evaluation of S100B protein expression in the human heart and its correlation with drug-related death.
METHOD: Left ventricular samples were collected from 74 serial forensic autopsies (15 overdose-related deaths; 59 non-overdose-related deaths) from 2007 to 2010. Tissue sections from each sample were immunostained for S100B protein by a commercial antibody.
RESULTS: The S100B protein was detected in the heart samples of all 15 cases of drug-related deaths; S100B immunoreactivity was mainly observed in the cytoplasm of cardiomyocytes and as globular deposits in the interstitial spaces. No reactivity or weak reactivity was found in the cardiomyocytes of the 59 subjects who died of other causes.
CONCLUSION: Our preliminary data show that the S100B protein accumulates in injured cardiomyocytes during drug-related sudden death. Given the near absence of S100B protein in the heart of subjects who died from causes other than drug overdose, S100B immunopositivity may be used as a new ancillary screening tool for the postmortem diagnosis of overdose-related cardiac death.
Authors:
Armando Faa; Giancarlo Senes; Annalisa Locci; Pietro Pampaloni; Maria Elena Pais; Bruno Piras; Ernesto d'Aloja; Gavino Faa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  67     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-15     Completed Date:  2013-06-12     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  821-6     Citation Subset:  IM    
Affiliation:
University of Cagliari, Department of Pathology, Cagliari, Italy. armando.faa@hotmail.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Autopsy
Biological Markers / analysis,  metabolism
Cause of Death
Child
Drug Overdose / metabolism*,  mortality
Female
Forensic Toxicology
Humans
Immunohistochemistry
Male
Myocardium / chemistry*
Nerve Growth Factors / analysis,  metabolism*
S100 Proteins / analysis,  metabolism*
Young Adult
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Nerve Growth Factors; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins
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