| S100B in brain damage and neurodegeneration. | |
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MedLine Citation:
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PMID: 12645009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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S100B is a calcium-binding peptide produced mainly by astrocytes that exert paracrine and autocrine effects on neurons and glia. Some knowledge has been acquired from in vitro and in vivo animal experiments to understand S100B's roles in cellular energy metabolism, cytoskeleton modification, cell proliferation, and differentiation. Also, insights have been gained regarding the interaction between S100B and the cerebral immune system, and the regulation of S100B activity through serotonergic transmission. Secreted glial S100B exerts trophic or toxic effects depending on its concentration. At nanomolar concentrations, S100B stimulates neurite outgrowth and enhances survival of neurons during development. In contrast, micromolar levels of extracellular S100B in vitro stimulate the expression of proinflammatory cytokines and induce apoptosis. In animal studies, changes in the cerebral concentration of S100B cause behavioral disturbances and cognitive deficits. In humans, increased S100B has been detected with various clinical conditions. Brain trauma and ischemia is associated with increased S100B concentrations, probably due to the destruction of astrocytes. In neurodegenerative, inflammatory and psychiatric diseases, increased S100B levels may be caused by secreted S100B or release from damaged astrocytes. This review summarizes published findings on S100B regarding human brain damage and neurodegeneration. Findings from in vitro and in vivo animal experiments relevant for human neurodegenerative diseases and brain damage are reviewed together with the results of studies on traumatic, ischemic, and inflammatory brain damage as well as neurodegenerative and psychiatric disorders. Methodological problems are discussed and perspectives for future research are outlined. |
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Authors:
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Matthias Rothermundt; Marion Peters; Jochen H M Prehn; Volker Arolt |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Microscopy research and technique Volume: 60 ISSN: 1059-910X ISO Abbreviation: Microsc. Res. Tech. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-03-19 Completed Date: 2003-11-07 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9203012 Medline TA: Microsc Res Tech Country: United States |
Other Details:
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Languages: eng Pagination: 614-32 Citation Subset: IM |
Copyright Information:
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Copyright 2003 Wiley-Liss, Inc. |
Affiliation:
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Department of Psychiatry, University of Muenster, D-48149 Muenster, Germany. rothermu@uni-muenster.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Astrocytes / metabolism*, pathology Brain / cytology, metabolism, pathology* Brain Injuries / metabolism, physiopathology* Humans Mice Nerve Degeneration / metabolism, physiopathology* Nerve Growth Factors / metabolism* Rats S100 Proteins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Nerve Growth Factors; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins |
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