Document Detail

S100B Protein concentration in milk-formulas for preterm and term infants. Correlation with industrial preparation procedures.
MedLine Citation:
PMID:  18384096     Owner:  NLM     Status:  MEDLINE    
Human milk S100B protein possesses important neurotrophic properties. However, in some conditions human milk is substituted by milk formulas. The aims of the present study were: to assess S100B concentrations in milk formulas, to verify any differences in S100B levels between preterm and term infant formulas and to evaluate the impact of industrial preparation at predetermined phases on S100B content. Two different set of samples were tested: (i) commercial preterm (n = 36) and term (n = 36) infant milk formulas; ii) milk preterm (n = 10) and term infant (n = 10) formulas sampled at the following predetermined industrial preparation time points: skimmed cow milk (Time 0); after protein sources supplementation (Time 1); after pasteurization (Time 2); after spray-drying (Time 3). Our results showed that S100B concentration in preterm formulas were higher than in term ones (p < 0.01). In addition, S100B concentrations during industrial preparation showed a significant increase (p < 0.001) at Time 1 followed by a slight decrease (p > 0.05) at Time 2, whereas a significant (p < 0.001) dip was observed at Time 3. In conclusion, S100B showed a sufficient thermostability to resist pasteurization but not spry-drying. New feeding strategies in preterm and term infants are therefore warranted in order to preserve S100B protein during industrial preparation.
Francesco Nigro; Luigi Gagliardi; Sabina Ciotti; Fabio Galvano; Amedeo Pietri; Gabriella Lucia Tina; Daniela Cavallaro; Luca La Fauci; Leonardo Iacopino; Matteo Bognanno; Giovanni Li Volti; Antonio Scacco; Fabrizio Michetti; Diego Gazzolo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  52     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-14     Completed Date:  2008-08-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  609-13     Citation Subset:  IM    
Department of Maternal, Fetal and Neonatal Health, G. Garibaldi Hospital, Catania, Italy.
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MeSH Terms
Drug Stability
Food Handling / methods
Hot Temperature
Infant Formula / chemistry*
Infant, Newborn
Infant, Premature*
Milk / chemistry*
Nerve Growth Factors / analysis*
S100 Proteins / analysis*
Reg. No./Substance:
0/Nerve Growth Factors; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins

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