Document Detail


S100A9 in BALF is a candidate biomarker of idiopathic pulmonary fibrosis.
MedLine Citation:
PMID:  22209187     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause, and the prognosis remains poor. On the other hand, other fibrotic interstitial pneumonias such as idiopathic nonspecific interstitial pneumonia (I-NSIP) and collagen vascular disease-associated interstitial pneumonia (CVD-IP) resemble IPF, but they respond to therapy and the prognosis is better. We searched for biomarkers to distinguish IPF from other fibrotic interstitial pneumonias and investigated whether S100A9 could be useful for discriminating types of fibrotic interstitial pneumonia based on our preliminary proteomic findings. METHODS: We measured S100A9 levels in serum and bronchoalveolar lavage fluid (BALF) from 28 patients with IPF, 15 with I-NSIP, 20 with cryptogenic organizing pneumonia (COP), 35 with CVD-IP and 23 healthy individuals (controls) using enzyme-linked immunosorbent assays. S100A9 in the lung was also immunohistochemically localized. RESULTS: S100A9 levels in BALF, but not in serum, were significantly elevated in patients with IPF compared with I-NSIP, COP, CVD-IP and healthy individuals. S100A9 immunoreactivity was localized mainly in macrophages and neutrophils in lung specimens from patients with IPF. The results of receiver operating characteristic (ROC) curve analysis showed that BALF S100A9 levels had sufficient specificity and sensitivity to distinguish IPF from I-NSIP and CVD-IP. CONCLUSION: S100A9 in BALF might serve as a candidate biomarker to discriminate between IPF and other fibrotic interstitial pneumonias.
Authors:
Atsuko Hara; Noriho Sakamoto; Yuji Ishimatsu; Tomoyuki Kakugawa; Shota Nakashima; Shintaro Hara; Misato Adachi; Hanako Fujita; Hiroshi Mukae; Shigeru Kohno
Related Documents :
4761607 - Lymphoblastic response to autologous colon epithelial cells in ulcerative colitis in vi...
16376117 - Plasma d-lactate as a potential early marker for colon ischaemia after open aortic reco...
2396947 - Quality of life after restorative proctocolectomy.
6600227 - Association of primary sclerosing cholangitis with hla-b8.
17249297 - Vulvar disease update.
11111227 - Acute confusional states in patients undergoing hip surgery. a prospective observation ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-30
Journal Detail:
Title:  Respiratory medicine     Volume:  -     ISSN:  1532-3064     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Multifocal cutaneous metastases from squamous cell carcinoma of hard palate.
Next Document:  Premorbid intelligence and educational level in bipolar and unipolar disorders: A Danish draft board...