| S100 beta protein is increased in fetuses with neural tube defect. | |
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MedLine Citation:
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PMID: 20036852 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the levels of S100 beta protein (S100B) in the serum of fetuses with neural tube defects (NTD), and their mother. Samples from 20 fetuses with NTD and 30 controls at the same gestational age, and their mothers, were studied. S100B protein levels were determined using Lia-mat Sangtec. kit. S100B concentrations were significantly higher in NTD fetuses (median 2.71 microg/L) than in control subjects (median 0.98 microg/L). Increased S100B levels were also found in mothers carrying fetuses with NTD compared to control and uncomplicated pregnancies. This study indicates that NTD is associated with increased serum concentration of S100B in fetuses and mothers. Moreover, it gives information on S100B levels in the fetal circulation in early-mid gestation. |
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Authors:
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Emanuela Marinoni; Alessandro Frigiola; Diego Gazzolo; Papaleo Greco; Antonella Vimercati; Massimo Moscarini; Raul Abella; Romolo Di Iorio |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-01 |
Journal Detail:
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Title: Frontiers in bioscience (Elite edition) Volume: 2 ISSN: 1945-0508 ISO Abbreviation: Front Biosci (Elite Ed) Publication Date: 2010 |
Date Detail:
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Created Date: 2009-12-28 Completed Date: 2010-07-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485240 Medline TA: Front Biosci (Elite Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 47-51 Citation Subset: IM |
Affiliation:
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Centre for Scientific Research, San Pietro Hospital, Fatebenefratelli, Rome, Italy. emanuelamarinoni@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Case-Control Studies Female Fetal Blood / chemistry* Humans Nerve Growth Factors / blood* Neural Tube Defects / blood* Pregnancy S100 Proteins / blood* Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Nerve Growth Factors; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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