Document Detail

S-propyl cysteine reduces the secretion of apolipoprotein B100 and triacylglycerol by HepG2 cells.
MedLine Citation:
PMID:  12044824     Owner:  NLM     Status:  MEDLINE    
A number of sulfur-containing amino acids and peptides are found in allium plants such as onion and garlic that have physiologic functions. In HepG2 cells, S-propyl cysteine decreased the secretion of apolipoprotein B100. The compound reduced the secretion of newly synthesized triacylglycerol and cholesterols from radiolabeled acetate. We associated the decrease of apolipoprotein B100 secretion to the length of the acyl-chain of the sulfur-containing amino acids. The present study suggests that foods containing S-propyl cysteine including onions have beneficial effects.
Seo-young Han; Ying Hu; Takahiko Anno; Teruyoshi Yanagita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  18     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-04     Completed Date:  2002-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  505-9     Citation Subset:  IM    
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, Saga 840-8502, Japan
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MeSH Terms
Allium / chemistry*
Apolipoprotein B-100
Apolipoproteins B / drug effects*,  secretion
Cholesterol / secretion
Culture Media
Cysteine / analogs & derivatives*,  pharmacology*
Plant Extracts / pharmacology
Triglycerides / secretion*
Tumor Cells, Cultured
Reg. No./Substance:
0/Apolipoprotein B-100; 0/Apolipoproteins B; 0/Culture Media; 0/Plant Extracts; 0/Triglycerides; 52-90-4/Cysteine; 57-88-5/Cholesterol; 65309-79-7/S-propylcysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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