Document Detail

S-perindopril assay using a potentiometric, enantioselective membrane electrode.
MedLine Citation:
PMID:  10467314     Owner:  NLM     Status:  MEDLINE    
A potentiometric, enantioselective membrane electrode based on graphite paste (graphite powder and paraffin oil) has been constructed. The graphite paste is impregnated with a 10(-3) mol/L 2-hydroxy-3-trimethylammoniopropyl-beta-cyclodextrin (as chloride salt) solution. The potentiometric, enantioselective membrane electrode can be used reliably for enantiopurity tests of S-perindopril using a chronopotentiometric (zero current) technique, in the 10(-5)-10(-2) mol/L concentration range (detection limit 5 x 10(-6) mol/L), with an average recovery of 99.58% (RSD = 0.33%). The enantioselectivity was determined over R-perindopril and D-proline. The response characteristics of the enantioselective, potentiometric membrane electrode were also determined for R-perindopril. It was shown that L-proline is the main interfering compound. The surface of the electrode can be regenerated simply by polishing, obtaining a fresh surface ready to be used in a new assay.
R I Stefan; J K Van Staden; H Y Aboul-Enein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chirality     Volume:  11     ISSN:  0899-0042     ISO Abbreviation:  Chirality     Publication Date:  1999  
Date Detail:
Created Date:  1999-10-25     Completed Date:  1999-10-25     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  8914261     Medline TA:  Chirality     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  631-4     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Wiley-Liss, Inc.
Department of Chemistry, University of Pretoria, Pretoria 0002, South Africa.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / analysis*
Hydrogen-Ion Concentration
Perindopril / analysis*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 82834-16-0/Perindopril

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