Document Detail


S-nitrosylation: integrator of cardiovascular performance and oxygen delivery.
MedLine Citation:
PMID:  23281416     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Delivery of oxygen to tissues is the primary function of the cardiovascular system. NO, a gasotransmitter that signals predominantly through protein S-nitrosylation to form S-nitrosothiols (SNOs) in target proteins, operates coordinately with oxygen in mammalian cellular systems. From this perspective, SNO-based signaling may have evolved as a major transducer of the cellular oxygen-sensing machinery that underlies global cardiovascular function. Here we review mechanisms that regulate S-nitrosylation in the context of its essential role in "systems-level" control of oxygen sensing, delivery, and utilization in the cardiovascular system, and we highlight examples of aberrant S-nitrosylation that may lead to altered oxygen homeostasis in cardiovascular diseases. Thus, through a bird's-eye view of S-nitrosylation in the cardiovascular system, we provide a conceptual framework that may be broadly applicable to the functioning of other cellular systems and physiological processes and that illuminates new therapeutic promise in cardiovascular medicine.
Authors:
Saptarsi M Haldar; Jonathan S Stamler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2013-01-02
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-03-11     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  101-10     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport, Active
Cardiovascular Diseases / metabolism*,  pathology,  therapy
Humans
Nitric Oxide / metabolism*
Oxygen / metabolism*
Grant Support
ID/Acronym/Agency:
AI080633/AI/NIAID NIH HHS; HL075443/HL/NHLBI NIH HHS; HL086614/HL/NHLBI NIH HHS; HL095463/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
31C4KY9ESH/Nitric Oxide; S88TT14065/Oxygen
Comments/Corrections

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