| S-nitrosylation: integrator of cardiovascular performance and oxygen delivery. | |
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MedLine Citation:
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PMID: 23281416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Delivery of oxygen to tissues is the primary function of the cardiovascular system. NO, a gasotransmitter that signals predominantly through protein S-nitrosylation to form S-nitrosothiols (SNOs) in target proteins, operates coordinately with oxygen in mammalian cellular systems. From this perspective, SNO-based signaling may have evolved as a major transducer of the cellular oxygen-sensing machinery that underlies global cardiovascular function. Here we review mechanisms that regulate S-nitrosylation in the context of its essential role in "systems-level" control of oxygen sensing, delivery, and utilization in the cardiovascular system, and we highlight examples of aberrant S-nitrosylation that may lead to altered oxygen homeostasis in cardiovascular diseases. Thus, through a bird's-eye view of S-nitrosylation in the cardiovascular system, we provide a conceptual framework that may be broadly applicable to the functioning of other cellular systems and physiological processes and that illuminates new therapeutic promise in cardiovascular medicine. |
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Authors:
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Saptarsi M Haldar; Jonathan S Stamler |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2013-01-02 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 123 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-02 Completed Date: 2013-03-11 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 101-10 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine and Cardiovascular Division, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, Ohio, USA. saptarsi.haldar@case.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport, Active Cardiovascular Diseases / metabolism*, pathology, therapy Humans Nitric Oxide / metabolism* Oxygen / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AI080633/AI/NIAID NIH HHS; HL075443/HL/NHLBI NIH HHS; HL086614/HL/NHLBI NIH HHS; HL095463/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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